Bioavailability of diazepam after intravenous, oral and rectal administration in adult epileptic patients.
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چکیده
منابع مشابه
Comparison between rectal administration of diazepam in solution and intravenous administration for management of convulsive disorders in infants and children
In order to compare rectal and intravenous(IV) administration of diazepam for management of convulsions,a prospective cross-sectional case-control study was conducted on 94 convulsive infants and children referring to the Emergency department of the university hospital No.1 in Kerman.all children were randomly divided into two groups.the patients were matched with regard to the cause,type,durat...
متن کاملIntravenous administration of diazepam in patients
was 17-9 + 1-4 mg (M ± SEM) compared with 27 ± 5-4 mg in controls (p < 0 01). Dose correlated significantly with serum albumin (p < 0-05). Baseline mean dominant frequency (MDF) and slow wave index (SWI) significantly correlated with albumin (p < 0 01). After diazepam, the MDF decreased and SWI increased. The change was greatest at the time of maximal clinical response. It was greater in liver ...
متن کاملRectal absorption of diazepam in epileptic children.
The absorption of diazepam after rectal administration was studied in children with epilepsy. When given as a solution, diazepam was rapidly absorbed and produced serum diazepam concentrations above 200 ng/ml within 10 minutes in most children. However, a commercial suppository formulation was absorbed slowly and cannot be recommended for urgent treatment of fits. There is a need in the UK for ...
متن کاملA clinical trial of single dose rectal and oral administration of diazepam for the prevention of serial seizures in adult epileptic patients.
The clinical anticonvulsant efficacy of single dose rectal and oral administration of diazepam 20 mg was examined in two double-blind placebo-controlled trials in adult epileptic patients. All subjects suffered from drug resistant epilepsy and frequently experienced serial seizures. Diazepam was administered rectally as a new experimental suppository formulation immediately after a seizure and ...
متن کاملAzathioprine pharmacokinetics after intravenous, oral, delayed release oral and rectal foam administration.
BACKGROUND 6-Mercaptopurine and its prodrug azathioprine are effective medications for refractory inflammatory bowel disease. However, use of these drugs has been limited by concerns about their toxicity. Colonic delivery of azathioprine may reduce its systemic bioavailability and limit toxicity. AIM To determine the bioavailability of 6-mercaptopurine after administration of azathioprine via...
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 1982
ISSN: 0306-5251
DOI: 10.1111/j.1365-2125.1982.tb01397.x